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Cristina suffers a strange accident and is in a coma. Valeria comes into contact with Veneno's family while trying to find out what has happened. The end is near and Valeria will fight to fulfill Cristina's last wish.

In 2003, Cristina is imprisoned, in a men's prison. This will lead her to relive her darkest traumas and put her essence aside in order to stay alive in such a hostile universe. The essence that he decides to recover at all costs in the present, obsessing over being a television star again although falling more and more into dark habits and attitudes that will diminish Paca's energy and that will turn Valeria's need to publish the book into something urgent.

After the end of the 'Mississippi' first, and the 'Pelican' later, Cristina is seen outside the world of television. After touring Spain doing small bowling, Angelo will lead her by the hand into the abyss. Today, Valeria has changed her life completely. She lives in Seville with her boyfriend and with a solid job offer. Everything seems to be going perfectly until she receives a call from Paca: Cristina is in the hospital. Valeria must decide whether to stay away or come back to help her idol rebuild her past together and finish the book that Cristina clings to as her only hope.

Cristina Ortiz, La Veneno, lands in 'Tonight we crossed the Mississippi'. Pepe cannot settle for just one program and invites La Veneno to be a regular contributor in exchange for doing what the public demands: delving into his past. If Cristina wants to leave the streets and enter fully into the world of television for which she seems to be predestined, she will have to face the demons of her past and re-incorporate her family and Adra into her life.

In the 90s, Joselito barely survived in Madrid. He is fired from the kitchen of a hospital for his "ways" and is seen on the street. It is at that moment when he meets Cristina Onassis, a trans woman who introduces him to the world of prostitution in Madrid, thus arriving at Parque del Oeste for the first time. At present, Veneno is completely unleashed by the excitement caused by her return to television, which causes Valeria a great lack of control because she cannot keep up with the frenetic pace of Cristina's life.

In the middle of a compilation of Cristina's life, Valeria also faces her transit. She lives a physical and psychological change that will lead her to consider and discover the range of possibilities that exist around identity. Also to want to carry their sexuality to the end. Sexual awakening that he shares with Joselito (Cristina) falling in love in the past when he meets Tom?s, a friend of the family he lives with after escaping from Adra: Los Romero.

Determined to write the book on Veneno's memories, Valeria runs into more difficulties than she imagined. There is something important in Cristina's childhood, but she dodges it and refuses to talk about that part of her past: a difficult childhood in Adra, where a young Joselito has to face rejection from other children and even from his own. mother, who does not look favorably on the boy's mannered forms. Thus, Valeria will have to use all the weapons at her disposal to try to understand what happened during those years that forever marked the life of Veneno.

When Valeria was a little girl, she never understood why people called her by a name that was not her own. The same thing happened to Cristina, by then misnamed "Joselito", who had to survive a violent and cruel childhood under the Spain of the sixties. Two women who were born in very different times but who, by chance or by destiny, end up united forever, when Valeria, a journalism student, decides to write a book about the life of the iconic Cristina, La Veneno.