Ep 149. Ellen Pompeo, Demetri Martin

Ellen DeGeneres welcomes actress Ellen Pompeo, who portrays Dr. Meredith Grey on ABC's long-running medical drama "Grey's Anatomy," to the show. Pompeo discusses her experience on the show, which has been on the air for 15 seasons, and talks about how she has evolved as an actor and a person since the show's inception. She also discusses her recent decision to sign a new two-year contract with the show and what that means for her future in the entertainment industry.

In addition to Pompeo, the show features an appearance by comedian and actor Demetri Martin. Martin talks about his new film "Dean," which he wrote, directed and starred in. He shares some insights into his creative process, as well as some of the challenges he faced while making the film. Martin also showcases some of his trademark humor, offering up some witty one-liners and clever observations.

During the show, Ellen also pays tribute to a teacher named Monsieur Martinez, who Ellen credits with changing her life. She shares some stories about how he influenced her and encourages viewers to thank teachers who have had a positive impact on their lives.

Throughout the episode, Ellen also takes some time to engage with her audience, playing games and offering up prizes. She also features the latest viral videos and shares some heartwarming stories and inspiring moments.

Overall, season 16 episode 149 of "The Ellen DeGeneres Show" offers up a mix of comedy, celebrity interviews, and engaging audience interaction. With big-name guests like Ellen Pompeo and Demetri Martin, as well as Ellen's trademark comedy and upbeat spirit, the show is sure to entertain and inspire viewers.