Watch The Human Centipede: First Sequence

Lindsay (Ashley C. Williams) and Jenny (Ashlynn Yennie), two American tourists in Germany, are drugged and involuntarily detained by crazed surgeon Dr. Josef Heiter (Dieter Laser) when they seek help at his house after they get a flat tire. The women awake in a makeshift medical ward. They witness Heiter kill a kidnapped truck driver (Rene de Wit) after Heiter informs him he is "not a match". Heiter secures a new male captive, Japanese tourist Katsuro (Akihiro Kitamura). The doctor explains that he is a world-renowned expert at separating Siamese twins, but dreams of making new creatures by sewing people together. He describes in detail how he will surgically connect his three victims mouth-to-anus, so that they share a single digestive system.

After Lindsay tries to escape and fails, Heiter explains that he had previously experimented with creating what he called a "three-dog", also joined mouth-to-anus. However, the three-dog died shortly after surgery. Heiter tells Lindsay that one dog tried to escape and that dog became the middle, and as punishment for her escape attempt, she will become the middle part of his centipede. Heiter performs the surgery, placing Katsuro at the front, Lindsay in the middle and Jenny at the rear. During his procedure, he severs the ligaments in his victims' knees so they cannot stand and are forced to crawl, and connects the victims together in a line with their mouths surgically attached to the anus of the person in front of them.

Once the operation is complete, Heiter attempts to train his centipede as a pet, often belittling Katsuro with racist insults and beating him with a crop when he becomes rebellious. When Katsuro defecates, Lindsay is forced to swallow his excrement while the doctor watches in delight. However, he eventually becomes irritated after being kept awake by the constant screaming of Katsuro (who, as the front part of the centipede, has his mouth free and is still able to speak) and the realization that Jenny is dying from blood poisoning. When two detectives, Kranz (Andreas Leupold) and Voller (Peter Blankenstein), visit the house to investigate the disappearance of tourists, Heiter decides to add them as replacements for Jenny in a new creation, a four-person centipede. He succeeds in drugging Voller, as the pair later leave the house to obtain a search warrant. The victims attempt to escape, and Katsuro attacks Heiter in the process. Their attempt to escape ultimately fails. Katsuro confesses to the doctor that he deserves his fate because he had treated his family poorly, then commits suicide by slitting his throat.

The detectives forcefully conduct separate searches as an injured Heiter hides near his swimming pool. Kranz finds the ward along with Heiter's victims. Voller begins to feel ill from the earlier drugging, and is later shot by Heiter. Kranz discovers Voller dead and gets shot by Heiter as well. Kranz responds by shooting Heiter in the head before dying. Back in the house, Jenny and Lindsay hold hands as Jenny dies from her infection. Lindsay sobs as she is left alone in the house, trapped between her deceased fellow captives. Her fate is left unknown.

The Human Centipede: First Sequence is a 2010 horror movie with a runtime of 1 hour and 32 minutes. It has received mostly poor reviews from critics and viewers, who have given it an IMDb score of 4.4 and a MetaScore of 33.