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Lorenzo's Oil is a 1992 American drama film directed by George Miller. The film is based on the true story of Augusto and Michaela Odone, a couple who fought against the medical establishment to find a cure for their son Lorenzo's rare and deadly disease, adrenoleukodystrophy (ALD). The film stars Nick Nolte and Susan Sarandon as Augusto and Michaela, and is notable for its portrayal of the Odone family's struggle, and for its frank discussion of the medical profession's reluctance to try unconventional treatments.

The film begins in 1984, when Lorenzo Odone, at the age of six, begins to exhibit strange and troubling symptoms. He becomes increasingly irritable, his speech begins to slur, and he experiences frequent seizures. Augusto and Michaela Odone take their son to several doctors, seeking a diagnosis, but are told that his condition is untreatable, and that he will likely die within two years.

Determined to save their son, the Odones begin to research the disease, and find that there are no effective treatments available. They decide to take matters into their own hands, and begin to investigate potential treatments for ALD. They consult with doctors and scientists, and eventually come up with a treatment regimen that includes a specially-formulated oil made from olive and rapeseed oils.

Despite initial skepticism from the medical establishment, the Odones persist in their efforts, and the film follows their ongoing struggle to find a cure for their son's disease. Along the way, they must navigate the politics and bureaucracy of the medical profession, and deal with the emotional toll the disease takes on their family.

The film is notable for its frank discussion of the medical profession's reluctance to try unconventional treatments. While Augusto and Michaela Odone are portrayed as determined and resourceful, the doctors they encounter are depicted as often dismissive of their efforts. The film is also notable for its portrayal of the Odones' emotional struggles, as they must confront the reality of their son's mortality, and the toll it takes on their marriage and family.

Nick Nolte and Susan Sarandon deliver powerful performances as Augusto and Michaela, capturing the emotional turmoil of their characters with nuance and depth. The film is also notable for its cinematography, which captures the stark beauty of the Odones' home in rural Virginia, as well as the desolate landscape of a hospital hallway.

Overall, Lorenzo's Oil is a moving and powerful portrayal of a family's struggle to find a cure for their son's rare and deadly disease. Despite the medical establishment's reluctance to try unconventional treatments, the Odones persist in their efforts, determined to save their son's life. The film is a testament to the power of human determination and love, and a sobering reminder of the difficulty of battling rare and incurable diseases.

Lorenzo is a 2004 animated movie with a runtime of 5 minutes. It has received mostly positive reviews from critics and viewers, who have given it an IMDb score of 6.5.