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The plot takes place at the beginning of the 20th century, in a reality where alchemy (ancient esoteric science that sought the transmutation of matter) is real, extremely developed and respected. Edward Elric and his younger brother Alphonse lived in the rural town of Resembool with their mother Trisha, their father Van Hohenheim having left them years prior as the brothers used his study to learn alchemy. When Trisha died of the plague, the brothers commit the taboo act of Human Transmutation to bring their mother back to life. But the transmutation backfires and the brothers ended up paying for more they bargain via the Law of Equivalent Exchange: Edward losing his left leg while Alphonse's entire being dragged into the Gate of Truth. Edward then sacrifices his right arm to save his brother's soul and binds it via a blood seal to a suit of armor. Edward is then given mechanical prosthetics known as "automail" in place of his missing limbs as he is invited by Colonel Roy Mustang to State Alchemist to research a means of restoring Alphonse's body. Upon passing the exam and given the title "Fullmetal Alchemist", Edward begins his quest with Alphonse to find the legendary philosopher's stone which could repair their bodies. However, they soon learn of the mysterious group known as the Homunculi.